Anti-NETO1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-NETO1/FITC Conjugated抗体

Anti-NETO1/FITC Conjugated抗体

商家询价

产品名称： Anti-NETO1/FITC Conjugated抗体

英文名称： Anti-NETO1/FITC

产品编号： YB--8588R-FITC

产品价格： null

产品产地： 中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围： 科研使用

上海钰博生物科技有限公司
  • 联系人 : 陈环环
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  • 邮编 : 200612
  • 所在区域 : 上海
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  • 传真 : 021-60514606
  • 邮箱 : shybio@126.com
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 Anti-NETO1/FITC Conjugated抗体

产品编号 YB-8588R-FITC
英文名称 Anti-NETO1/FITC
中文名称 FITC标记的脑低密度脂蛋白受体蛋白1抗体
别    名 BCTL1; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; BTCL1; Neto1; NETO1_HUMAN; Neuropilin and tolloid like 1; Neuropilin and tolloid-like protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NETO1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
NETO1 is a 533 amino acid protein that contains one LDL-receptor class A domain and two CUB domains and is either membrane-bound or secreted. Expressed as three alternatively spliced isoforms, the first two of which are retina-specific and the third of which is found in both retina and brain tissue, NETO1 is thought to be involved in the development and maintenance of neuronal circuitry, possibly playing a role in proper brain function. Human NETO1 shares 95% amino acid identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding NETO1 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function:
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.

Subunit:
Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains.

Subcellular Location:
Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Component of the postsynaptic density (PSD) of excitatory synapses. Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 1: Secreted (Potential).

Tissue Specificity:
Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.

Similarity:
Contains 2 CUB domains.
Contains 1 LDL-receptor class A domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications