BRN3A,转录因子Brn3蛋白抗体

产品编号HZ-3669R
英文名称BRN3A
中文名称转录因子Brn3蛋白抗体Brn3α
别 名Brain specific homeobox/POU domain protein 3A; Brn 3.0; BRN 3A; Brn3; Homeobox/POU domain protein RDC 1; Homeobox/POU domain protein RDC1; Oct T1; OctT1; POU Domain Class 4 Transcription Factor 1; POU4F1; RDC 1; RDC1.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
BRN3A,转录因子Brn3蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BRN3A
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BRN3A,转录因子Brn3蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012].

Function:
Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye.

DISEASE:
Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth.

Similarity:
Belongs to the POU transcription factor family. Class-4 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

BRN3A,转录因子Brn3蛋白抗体Database links:
Entrez Gene: 5457 Human
Entrez Gene: 18996 Mouse
Entrez Gene: 114503 Rat
Omim: 601632 Human
SwissProt: Q01851 Human
SwissProt: P17208 Mouse
SwissProt: P20266 Rat
Unigene: 654522 Human
Unigene: 246550 Mouse
Unigene: 232568 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录因子Brn3可能直接参与对轴突和树突生长能力的调控。